Alexandra Benavente-Perez, PhD

Associate Clinical Professor
Biological and Vision Sciences

Bio

Alexandra Benavente received her degree in Optometry and Optics from the College of Science and Medicine in Valladolid, Spain; MS in Investigative Ophthalmology and Vision Science from the University of Manchester, UK; and PhD in Vision Science from Aston University, Birmingham, UK.

During her first years at SUNY, Dr. Benavente was a Research Associate funded through the SUNY Research Foundation and an Adjunct Assistant Professor at the college. She later took the position of Assistant Clinical Professor in the Department of Clinical Education, followed by Associate Clinical Professor in the Department of Biological Sciences. She has been a part of the clinical research effort at the college through the Clinical Vision Research Center from its creation in 2013, where she has been Principal Investigator in a multi-center research study and sub-Investigator in more than 20 clinical studies.

Since joining SUNY Optometry, Sandra has published 15 peer-reviewed research papers, 2 book chapters and 80 conference abstracts on her doctoral research, work on experimental myopia models and ongoing multidisciplinary collaborations.

She has served as Chair of the Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting Program Committee (Anatomy section), and is an appointed member of the Scientific Committees of the American Academy of Optometry, and International Myopia Conference.

She has received the Josh Wallman Memorial Award/Zeiss Young Scientist Award in Myopia Research at the International Myopia Conference, and the American Academy of Optometry Professional Career Development Award.

Education

  • PhD, Visual Neuroscience, Aston University, 2007
  • MS, Investigative Ophthalmology and Vision Sciences, University of Manchester Institute of Science and Technology, 2003
  • OD, Optometry and Optics, School of Medicine and Sciences, Universidad de Valladolid. Spain, 2000

Residency/Other Post Graduate Training

  • Spatial and temporal properties of defocus integration for refractive and eye growth control - SUNY College of Optometry, 2012
  • Ocular vascular performance in myopia - City University, 2009
  • The vascular relationship between glaucoma and alzheimer’s disease - Aston University, 2009

Awards/Honors

  • Josh Wallman Memorial Award/Zeiss Young Scientist Award in Myopia Research , 2017
  • ARVO Leadership Development Program for Women, 2016
  • Sek-Jin Chew Myopia Travel Award , 2012
  • International Travel Award, 2009
  • Research Presentation Award, 2008
  • Travel Award, 2007
  • Travel Award, 2005

Professional Experience

  • Associate Clinical Professor, SUNY College of Optometry, 2017 - Present
  • Assistant Clinical Professor, SUNY College of Optometry, 2012 - 2017
  • Post-Doctoral Research Associate, SUNY College of Optometry, 2009 - 2012
  • Post-Doctoral Research Fellow, Aston University, 2007 - 2009
  • Post-Doctoral Research Fellow, City University, 2007 - 2009
  • Principal Optometrist, Private Practice, 2005 - 2009
  • Optometrist, Private Practice, 2000 - 2002

Teaching Interests

Clinical skills
Evidence-based clinical practice
Cultural competence
Research methods
Experimental models
Emmetropization

Courses Taught Most Recent Academic Year

ELC 560
Spanish for Optometrists

Research Interests

From experimental studies, we know that eyes use visual information to adjust their growth and how they are focused. My two main research lines study myopia, in particular the role of the peripheral retina in myopia control, and the development of myopic pathology. Our lab has found that the timing and duration of imposed defocus across the retina is important and influences eye growth and refractive development. Brief daily interruption periods to negative defocus prevent myopia development, but once the eye starts to compensate, the same brief interruptions are not enough to slow myopia progression. In addition, interactions between the refractive asymmetry of the peripheral retina and the visual defocus experienced may be associated with eye growth, suggesting that peripheral refraction is a factor in the progression of myopia, and can offer a means to control it.

The structural characteristics of a myopic eye include an elongated vitreous chamber, which in high myopia is related to a stretched and progressively thinned retina. The myopic elongation increases the risk of retinal changes and ocular diseases, including glaucoma and macular degeneration among others. This is of significant clinical importance because degenerative myopia is a leading cause of blindness. Our lab has evidence of structural and functional changes in eyes with moderate myopia that cannot be explained by simple growth scaling. We have also reported compromised ocular hemodynamics and thinner choroids in moderate myopic eyes with no degeneration, which has been later confirmed by others. I hypothesize that these early anatomical and functional changes in both experimental animal and human eyes may be early indicators of the development of posterior pole complications associated with myopia progression.

Clinical Interests

Primary care
Myopia control
Glaucoma

Publications

  • Optical mechanisms regulating emmetropization and refractive errors: evidence from animal models, Clin Exp Optom, 103(1): 55-67, 2019
  • Short Interruptions of Imposed Hyperopic Defocus Earlier in Treatment are More Effective at Preventing Myopia Development, Nature Scientific Reports , 9(1): 11459, Array
  • International Myopia Institute (IMI) - Clinical Myopia Control Trials and Instrumentation report, Invest Ophthalmol Vis Sci, 60(3): M132-M160, Array
  • Gene expression in response to optical defocus of opposite signs reveals bidirectional mechanism of visually guided eye growth, PLOS Biology, 16(10): e2006021, 2018
  • Axial Eye Growth and Refractive Error Development Can Be Modified by Exposing the Peripheral Retina to Relative Myopic or Hyperopic Defocus, Invest Ophthalmol Vis Sci , 55(10): 6765-73, 2014
  • The effect of simultaneous negative and positive defocus on eye growth and development of refractive state in marmosets., Investigative ophthalmology & visual science, 53(10): 6479-87, 2012
  • Ocular Blood Flow Measurements In Healthy Human Myopic Eyes, Graefes Arch Clin Exp Ophthalmol , 248(11): 1587-94, 2010
  • Reproducibility-Repeatability of Choroidal Thickness Calculation Using OCT, Optom Vis Sci, 87(11): 867-72, 2010
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