Miduturu Srinivas, PhD

Professor
Biological and Vision Sciences

Bio

Intercellular Communication in the Lens and Retinal Glial cells

Education

  • PhD, , University of Florida College of Medicine,
  • PhD, Doctor of Optometry, University of Florida College of Medicine,

Courses Taught Most Recent Academic Year

BVS 205FA
Pharmacology I

Publications

  • Suppression of connexin 43 phosphorylation promotes astrocyte survival and vascular regeneration in proliferative retinopathy., Proceedings of the National Academy of Sciences of the United States of America, 115(26): E5934-E5943, 2018
  • Human diseases associated with connexin mutations., Biochimica et biophysica acta, 1860(1): 192-201, 2018
  • Identification and Functional Assessment of Age-Dependent Truncations to Cx46 and Cx50 in the Human Lens., Investigative ophthalmology & visual science, 57(13): 5714-5722, 2016
  • Syndromic deafness mutations at Asn 14 differentially alter the open stability of Cx26 hemichannels., The Journal of general physiology, 148(1): 25-42, 2016
  • Aberrant connexin26 hemichannels underlying keratitis-ichthyosis-deafness syndrome are potently inhibited by mefloquine., The Journal of investigative dermatology, 135(4): 1033-1042, 2015
  • Connexin 46 (cx46) gap junctions provide a pathway for the delivery of glutathione to the lens nucleus., The Journal of biological chemistry, 289(47): 32694-702, 2014
  • Altered inhibition of Cx26 hemichannels by pH and Zn2+ in the A40V mutation associated with keratitis-ichthyosis-deafness syndrome., The Journal of biological chemistry, 289(31): 21519-32, 2014
  • Functional effects of Cx50 mutations associated with congenital cataracts., American journal of physiology. Cell physiology, 306(3): C212-20, 2014
  • Connexin channel modulators and their mechanisms of action., Neuropharmacology, 75(Array): 517-24, 2013
  • The D50N mutation and syndromic deafness: altered Cx26 hemichannel properties caused by effects on the pore and intersubunit interactions., The Journal of general physiology, 142(1): 3-22, 2013
  • The N-terminal half of the connexin protein contains the core elements of the pore and voltage gates., The Journal of membrane biology, 245(8): 453-63, 2012
  • Triarylmethanes, a new class of cx50 inhibitors., Frontiers in pharmacology, 3(Array): 106, 2012
  • Connexin43 mutation causes heterogeneous gap junction loss and sudden infant death., Circulation, 125(3): 474-81, 2012
  • Mechanism of inhibition of connexin channels by the quinine derivative N-benzylquininium., The Journal of general physiology, 139(1): 69-82, 2012
  • Differentially altered Ca2+ regulation and Ca2+ permeability in Cx26 hemichannels formed by the A40V and G45E mutations that cause keratitis ichthyosis deafness syndrome., The Journal of general physiology, 136(1): 47-62, 2010
  • Interaction between Connexin50 and mitogen-activated protein kinase signaling in lens homeostasis., Molecular biology of the cell, 20(10): 2582-92, 2009
  • Loop gating of connexin hemichannels involves movement of pore-lining residues in the first extracellular loop domain., The Journal of biological chemistry, 284(7): 4484-93, 2009
  • Divalent cations regulate connexin hemichannels by modulating intrinsic voltage-dependent gating., The Journal of general physiology, 132(3): 315-27, 2008
  • Optimal lens epithelial cell proliferation is dependent on the connexin isoform providing gap junctional coupling., Investigative ophthalmology & visual science, 48(12): 5630-7, 2007
  • Block of specific gap junction channel subtypes by 2-aminoethoxydiphenyl borate (2-APB)., The Journal of pharmacology and experimental therapeutics, 319(3): 1452-8, 2006
  • Functional characterization of a naturally occurring Cx50 truncation., Investigative ophthalmology & visual science, 47(10): 4474-81, 2006
  • Mefloquine effects on the lens suggest cooperative gating of gap junction channels., The Journal of membrane biology, 211(3): 163-71, 2006
  • Regulation of connexin hemichannels by monovalent cations., The Journal of general physiology, 127(1): 67-75, 2006
  • Transfection of mammalian cells with connexins and measurement of voltage sensitivity of their gap junctions., Nature protocols, 1(4): 1799-809, 2006
  • New possible roles for aquaporin-4 in astrocytes: cell cytoskeleton and functional relationship with connexin43., FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 19(12): 1674-6, 2005
  • Correlative studies of gating in Cx46 and Cx50 hemichannels and gap junction channels., Biophysical journal, 88(3): 1725-39, 2005
  • Potent block of Cx36 and Cx50 gap junction channels by mefloquine., Proceedings of the National Academy of Sciences of the United States of America, 101(33): 12364-9, 2004
  • Molecular cloning and functional expression of zfCx52.6: a novel connexin with hemichannel-forming properties expressed in horizontal cells of the zebrafish retina., The Journal of biological chemistry, 279(4): 2913-21, 2004
  • Closure of gap junction channels by arylaminobenzoates., Molecular pharmacology, 63(6): 1389-97, 2003
  • Prospects for rational development of pharmacological gap junction channel blockers., Current drug targets, 3(6): 455-64, 2002
  • Virtual cloning, functional expression, and gating analysis of human connexin31.9., American journal of physiology. Cell physiology, 283(3): C960-70, 2002
  • Evidence for a role of the N-terminal domain in subcellular localization of the neuronal connexin36 (Cx36)., Journal of neuroscience research, 69(4): 448-65, 2002
  • Growth-suppressive function of human connexin32 in a conditional immortalized mouse hepatocyte cell line., In vitro cellular & developmental biology. Animal, 37(9): 589-98, 2001
  • Quinine blocks specific gap junction channel subtypes., Proceedings of the National Academy of Sciences of the United States of America, 98(19): 10942-7, 2001
  • Calmodulin kinase pathway mediates the K+-induced increase in Gap junctional communication between mouse spinal cord astrocytes., The Journal of neuroscience : the official journal of the Society for Neuroscience, 21(17): 6635-43, 2001
  • How to close a gap junction channel. Efficacies and potencies of uncoupling agents., Methods in molecular biology (Clifton, N.J.), 154(Array): 447-76, 2001
  • Identification and functional expression of HCx31.9, a novel gap junction gene., Cell communication & adhesion, 8(4-6): 173-8, 2001
  • Molecular and functional diversity of neural connexins in the retina., The Journal of neuroscience : the official journal of the Society for Neuroscience, 20(22): 8331-43, 2000
  • Properties of gap junction channels formed by Cx46 alone and in combination with Cx50., Biophysical journal, 79(4): 1954-66, 2000
  • Voltage gating properties of channels formed by a skate retinal connexin., The Biological bulletin, 199(2): 165-8, 2000
  • Temporal expression of neuronal connexins during hippocampal ontogeny., Brain research. Brain research reviews, 32(1): 57-71, 2000
  • TPA induced expression and function of human connexin 26 by post-translational mechanisms in stably transfected neuroblastoma cells., Cell structure and function, 24(6): 435-41, 1999
  • Functional properties of channels formed by the neuronal gap junction protein connexin36., The Journal of neuroscience : the official journal of the Society for Neuroscience, 19(22): 9848-55, 1999
  • Voltage dependence of macroscopic and unitary currents of gap junction channels formed by mouse connexin50 expressed in rat neuroblastoma cells., The Journal of physiology, 517 ( Pt 3)(Array): 673-89, 1999
Did You Find What You Need ?

Thank you for your feedback!

Up